MapPathSlowUsingIISCore Error

[Guest]

Anyone has any idea why the following error happens ? The path does exist
and the problem seems to appear sporadically.

System.Exception: Exception thrown initializing DBSystemValues collection
---> System.Web.HttpException: Failed to map the path '/SomeFile.xml/'.
at
System.Web.Hosting.ISAPIWorkerRequestInProcForIIS6.MapPathSlowUsingIISCore(String path)
at System.Web.Hosting.ISAPIWorkerRequest.MapPath(String path)
at System.Web.HttpRequest.MapPath(String virtualPath, String
baseVirtualDir, Boolean allowCrossAppMapping)
at System.Web.HttpRequest.MapPath(String virtualPath)