Netscape failed to find a part of the file path

[Guest]

I got a problem when users use Netscape to upload document to webserver. All
things are working fine with IE users. The warning message I got is something
like

Diagnostic Data
Could not find a part of the path "E:\something\ "
Call stack:
System.IO.__Error.WinIOError

Stack trace:
at System.IO.__Error.WinIOError(Int32 errorCode, String str)
at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess
access, FileShare share, Int32 bufferSize, Boolean useAsync, String msgPath,
Boolean bFromProxy)
at System.IO.FileStream..ctor(String path, FileMode mode)
at System.Web.HttpPostedFile.SaveAs(String filename)