the center of the keyboard. You want something that you can reach
easily, without significant stretching and without needing to watch
carefully when you return your hand to the home row. I'd personally be
inclined towards option 2.
Heck, that would really only require a slight remapping on my current
keyboard, at least to get parens accessible without shifting --
currently [/{ and ]/} are just to the right of P; I can see an advantage
to remapping those keys to be (/[ and )/], and putting { and } above 9
and 0 where the parens are now...
Of course, for me it's not worth customizing my keymapping, because I
end up working on a variety of machines often enough (frequently in the
sense of "fixing", rather than just trying to get my own work done).
Switching back and forth from a custom keymap to the standard one would
be confusing enough to counteract any gains I'd make from a more
ergonomic arrangement of keys. (Now, if I could convince everyone
worldwide to switch to (nationalized keyboards based off of) a
Dvorak-style arrangement, that'd be a different matter....
)